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Compared with mouse thymocytes, mouse ES cells contain higher levels of total genomic H3K4me3 and have higher H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In agreement with this, international decreases in H3K4me3 levels occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells forty seven In addition, there are dynamic modifications in H3K4me3 profiles at specific units of genes during ES cell differentiation. |
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